Journal article
The potential of intervening on childhood adversity to reduce socioeconomic inequities in body mass index and inflammation among Australian and UK children: A causal mediation analysis
N Priest, S Guo, D Gondek, M O'Connor, M Moreno-Betancur, S Gray, R Lacey, DP Burgner, S Woolfenden, H Badland, G Redmond, M Juonala, K Lange, S Goldfeld
Journal of Epidemiology and Community Health | BMJ PUBLISHING GROUP | Published : 2023
Abstract
Background Lower maternal education is associated with higher body mass index (BMI) and higher chronic inflammation in offspring. Childhood adversity potentially mediates these associations. We examined the extent to which addressing childhood adversity could reduce socioeconomic inequities in these outcomes. Methods We analysed data from two early-life longitudinal cohorts: the Longitudinal Study of Australian Children (LSAC; n=1873) and the UK Avon Longitudinal Study of Parents and Children (ALSPAC; n=7085). Exposure: low/medium (below university degree) versus high maternal education, as a key indicator of family socioeconomic position (0-1 year). Outcomes: BMI and log-transformed glycopr..
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Awarded by Medical Research Council
Funding Acknowledgements
& nbsp;The UK Medical Research Council (MRC) and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and NP and RL will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/Alspac/external/documents/grant-acknowledgements.pdf). This research was specifically funded by the National Institute of Health (NIH) (Grant ref: DK077659), Wellcome Trust and MRC (Grant ref: 07467/Z/05/Z). Access to ALSPAC data was supported by a University College London Global Engagement Award. This work was also supported by Australian Research Council Discovery Grant (grant number DP160101735) and was supported by the Victorian Government's Operational Infrastructure Support Program. MOC is supported by the Melbourne Children's LifeCourse initiative, funded by a Royal Children's Hospital Foundation Grant (2018-984). MMB is supported by Australian Research Council Discovery Early Career Award (DE190101326) and Australian National Health and Medical Research Council (NHMRC) Investigator Grant Emerging Leadership Level 2 (ID 2009572). SGo is supported by an NHMRC Practitioner Fellowship (APP1155290). HB is supported by an RMIT University VC Senior Research Fellowship. NP was supported by a NHMRC Career Development Fellowship (APP1123677). DB is supported by an NHMRC Investigator Grant (APP1175744). RL and DG's time on this study was supported by a UK Economic and Social Research Council grant (Grant ref: ES/P010229/1).